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Clinical Guidelines

Major liver disease guidelines from AASLD, EASL, and international consensus panels: translated into plain language so patients and caregivers can understand what the experts recommend and why.

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MASLD / MASH β€” Assessment & Nomenclature

Guidelines covering the diagnosis, screening, and classification of metabolic dysfunction–associated steatotic liver disease (formerly NAFLD/NASH).

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Cirrhosis & Portal Hypertension

Guidelines on diagnosing and managing cirrhosis and its associated complications such as clinically significant portal hypertension, varices, and preventing variceal bleeding.

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Nutrition & Treatment

This section contains nutrition guidance by EASL and AASLD for chronic liver disease patientys. There are also drug-specific guidance for FDA-approved (accelerated) therapies targeting MASH with fibrosis: who qualifies, monitoring protocols, and trial results.

EASL Practice Guidance 2019
Nutrition in Chronic Liver Disease (2019)

Plain-language summary of EASL's 2019 clinical guidelines on nutrition in cirrhosis. Covers protein targets, sarcopenia, obesity, vitamin D, bone disease, HE diet, and transplant nutrition.

20-50% Cirrhosis patients with malnutrition
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EASL Practice Guidance 2021
Managing Frailty, Sarcopenia, and Malnutrition in Cirrhosis (2021)

AASLD 2021 guidance on malnutrition, frailty, and sarcopenia in cirrhosis: assessment tools, nutrition targets, exercise recommendations, and monitoring schedules.

1.2-1.5 g/kg Daily protein target for adults with cirrhosis (based on ideal body weight)
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AASLD Practice Guidance FDA Accelerated Approval Oct 2024
Resmetirom (Rezdiffra) for MASH with Moderate-to-Advanced Fibrosis

Who qualifies for resmetirom, what non-invasive tests you need, how doctors monitor treatment response, drug interactions to watch for, and side effects β€” based on the MAESTRO-NASH trial results.

26–30% MASH resolution with resmetirom (vs 10% placebo) at 52 weeks
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AASLD Practice Guidance FDA Accelerated Approval Nov 2025
Semaglutide (Wegovy) for MASH with Moderate-to-Advanced Fibrosis

Who qualifies for semaglutide, the non-invasive testing pathway, how doctors monitor your response, and what side effects to expect β€” based on the ESSENCE trial and the AASLD's latest practice guidance.

62.9% MASH resolution with semaglutide (vs 34.3% placebo) at 72 weeks
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More Guidelines Coming Soon

We're expanding this library with additional society guidelines and consensus statements. Future additions will include:

AASLD HCC Surveillance EASL Alcohol-Related Liver Disease AASLD Autoimmune Hepatitis EASL Drug-Induced Liver Injury